The academic literature in research ethics has been marked in the past decade by a much broader focus on the need for the protection of developing communities subjected to international clinical trials. Because of the proximity of the revision of the Declaration of Helsinki, completed in October 2008, most papers have addressed the issue of a double standard of care following the use of placebo. However, other no less important issues, such as interactions between the lifestyles structures of low-income communities (...) and the efficiency of risk-minimising procedures also deserve attention. The purpose of this paper is to discuss forms of uncertainty involved in clinical trials in poor and low-income countries that are not addressed by conventional methods of risk assessment. Furthermore, the increase in size of risks that are identified by conventional assessment methods will be addressed. Besides, the difficulty in properly applying risk-minimising procedures will be discussed. Finally, this paper proposes the involvement of research ethics committees in the risk evaluation process and the establishment of national ethics evaluation systems. (shrink)

It is traditionally believed that cerebral activation (the presence of low voltage fast electrical activity in the neocortex and rhythmical slow activity in the hippocampus) is correlated with arousal, while deactivation (the presence of large amplitude irregular slow waves or spindles in both the neocortex and the hippocampus) is correlated with sleep or coma. However, since there are many exceptions, these generalizations have only limited validity. Activated patterns occur in normal sleep (active or paradoxical sleep) and during states of anesthesia (...) and coma. Deactivated patterns occur, at times, during normal waking, or during behavior in awake animals treated with atropinic drugs. Also, the fact that patterns characteristic of sleep, arousal, and waking behavior continue in decorticate animals indicates that reticulo-cortical mechanisms are not essential for these aspects of behavior. (shrink)

Journal of Political Philosophy, EarlyView.

_ Source: _Volume 53, Issue 2-4, pp 294 - 321 Manuscript London, British Library, Burney 330 contains an anonymous collection of grammatical sophisms, dating in all probability from early 13th-century France or England, and all based on problematic biblical, liturgical or religious propositions. After a presentation of the manuscript and collection, this article examines two analysis tools that are applied in the majority of the sophisms, viz. a distinction between three layers of grammatico-semantic perfection or completeness, and the grammatical and (...) semantic supposition doctrines. It appears that these sophisms pay prominent attention to improper or figurative supposition, but are not intended for highly advanced readers. These preliminary results suggest that the Burney Sophismata Collection constituted an exercise tool to support textbook-based instruction in theological grammar, which was developed by such masters as Peter the Chanter and William de Montibus in the late 12th and early 13th centuries. (shrink)

In describing the account of the εδη in the Phaedo, Burnet says, ‘they are explained in a peculiar vocabulary which is represented as that of a school. The technical terms are introduced by such formulas as “we say”’. Similarly Taylor has written of the ‘characteristic technical nomenclature’ used in the dialogues, of the ‘technicalities’ of the theory of εδη, of ‘the technical phrases of the Phaedo’ The validity of such language has been taken for granted by both these and many (...) other Platonic scholars. But the assumption which it represents—that Plato employed certain words in a significance peculiar to his use of them—carries such wide implications for the history and interpretation of his philosophy that it can hardly be accepted without further investigation. In this article I shall examine the evidence in fifth- and early fourth-century literature about these words which Plato or Socrates is alleged to have transformed into ‘technicalities’: first, εδος and δσ, which I shall assume to be more or less synonymous; second, the various terms used to describe the relation between εδη and particulars—,μετέχειν, κοινωνεν,παρεναι, νεναι,μιμησις,μοιωαις, and so on. (shrink)

We show that the enveloping space \ of a partial action of a Polish group G on a Polish space \ is a standard Borel space, that is to say, there is a topology \ on \ such that \\) is Polish and the quotient Borel structure on \ is equal to \\). To prove this result we show a generalization of a theorem of Burgess about Borel selectors for the orbit equivalence relation induced by a group action and also (...) show that some properties of the Vaught’s transform are valid for partial actions of groups. (shrink)

Branner, H.C. Humanismens krise.--Hansen, Martin A. Eneren og massen.

In orthodox quantum mechanics, it has virtually become the custom to identify properties of a physical system with operationally testable propositions about the system. The causes and consequences of this practice are explored mathematically in this paper. Among other things, it is found that such an identification imposes severe constraints on the admissible states of the physical system.